Left-sided tumors tend to be polyp shaped and are more likely to be tubular or villous adenocarcinomas. Right-sided tumors tend to be flat shaped and are more likely to be part of the mucinous subgroup of adenocarcinomas. Right-sided colon cancers and left-sided colorectal cancers may also have differences in their tumor shape and in their subtype of adenocarcinoma. Left-sided colon cancer has a better prognosis at advanced stages (stage III and stage IV / metastatic colorectal cancer). Right-sided colon cancer has a better prognosis in early stages (stage I and stage II). How are right-sided colon cancer and left-sided colorectal cancer different? The populations of normal gut bacteria (intestinal microbiome) that live in the large intestine vary between the right side of the colon and the left side of the colon and rectum.As digested food travels through the large intestine, the right and left sides are exposed to different nutrients and digestive substances, such as bile acids.The right and left sides of the colon develop from two different parts of the embryo, the midgut and the hindgut.Several factors likely contribute to the differences in right-sided colon cancers and left-sided colorectal cancers. Why are right sided colon cancers and left sided colon and rectal cancers different? Tumor sidedness gives information about the likely course of the disease (prognosis), and tumor location is a predictor of which treatments may be more or less effective for a particular colorectal cancer. Tumor location is both a prognostic factor and a predictive biomarker. Left-sided tumors, also called distal tumors, are located in the splenic flexure, descending colon, sigmoid colon, or rectum. Right-sided tumors, also known as proximal tumors, are located in the cecum, ascending colon, hepatic flexure, or the transverse colon. Often, colorectal cancer is referred to as “right sided” or “left sided”. Colorectal cancer (bowel cancer) can develop in any of these locations. The splenic flexure (left colic flexure) is the turning point between the transverse colon and descending colon. The hepatic flexure (right colic flexure) is the turning point between the ascending colon and transverse colon. The large intestine (bowel) is made up of 6 segments, cecum (caecum), ascending colon, transverse colon, descending colon, sigmoid colon, and rectum. 2007 21(6):929–34.Tumor location refers to the site of the primary tumor (tumour) of your colorectal cancer. Evaluation of the technical difficulty performing laparoscopic resection of a rectosigmoid carcinoma: visceral fat reflects technical difficulty more accurately than body mass index. Seki Y, Ojue M, Sekimoto M, Takiguchi S, Takemasa I, Ikeda M, et al. Single-incision laparoscopic versus conventional laparoscopic right hemicolectomy: a comparison of short-term surgical results. Analysis of vascular anatomy and lymph node metastases warrants radical segmental bowel resection for colon cancer. Yada H, Sawai K, Taniguichi H, Hoshima M, Katoh M, Takahashi T. Blood supply and anatomy of the upper abdominal organs. Minimally invasive colectomy: are the potential benefits realized? Dis Colon Rectum. Right colonic arterial anatomy: implications for laparoscopic surgery. Garcia-Ruiz A, Milsom JW, Ludwig KA, Marchesa P. Clinical syndrome in mentally deficient adults. Symptom-producing interposition of the colon. The Chilaiditi syndrome and associated volvulus of the transverse colon. 1993 176(1):55–8.įlores N, Ingar C, Sánchez J, Fernandez J, Lazarte C, Medina M, et al. Chilaiditi’s syndrome as a surgical and nonsurgical problem. Risaliti A, De Anna D, Terrosu G, Uzzau A, Carcoforo P, Bresadola F. Roentgen diagnosis of hepatodiaphragmatic interposition of the large intestine. Hepatodiaphragmatic interposition in children. Suprahepatic interposition of the colon and volvulus of the cecum. Fortschr Geb Rontgenstr Nuklearmed Erganzungsband. Zur Frage der Hepatoptose und Ptose im allgemeinen im Anschluss an drei F~ille von tempor~irer, partieller Leberverlagerung.
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